The Laboratory of Comparative Pathology (LCP) of the Research Animal Resource Center (RARC) is a full service
diagnostic lab offering clinical and anatomic pathology services. The LCP supports investigative staff utilizing
a variety of animal species as research models at Memorial Sloan-Kettering Cancer Center (MSKCC) as well as Weill
Cornell Medical College (WCMC) and Rockefeller University (RU), in addition to the Veterinary Services quarantine
and sentinel programs for animals housed at MSKCC and WMC.
The Genetically Engineered Mouse (GEM) Phenotyping Service is a component of the LCP which is dedicated to
providing extensive baseline phenotypic profiles of genetically engineered mice. Such a comprehensive
baseline characterization is invaluable to investigators unfamiliar with normal mouse anatomy, histology,
physiology and age- or strain-related background lesions and ensures appropriate correlation between
genotype and phenotype.
Clinical pathology services offered include: hematology (complete blood counts with white blood cell
differentials, serum biochemical panels, hormone levels); parasitology; microbiology (bacterial and fungal
identification, antimicrobial sensitivity); analysis of urine and other body fluids; serology for numerous
bacterial, viral and parasitic infectious agents; and, environmental monitoring. All tests are performed by
qualified laboratory professionals trained in veterinary laboratory techniques. The laboratory staff is
committed to research in improved diagnostics, reference range development, and state-of-the art assays.
New tests are continuously being added as experimental needs change. We also have a network of reference
laboratories available to provide tests that are not performed in-house.
Complete anatomic pathologic examinations, including gross and histopathologic analyses, are performed by
American College of Veterinary Pathologists (ACVP) board-certified veterinary anatomic pathologists.
In addition, examination of tissue biopsies and slide evaluations are available. Experienced histology
technicians provide complete histology services including tissue processing, paraffin embedding, and
sectioning. Routine stains such as hematoxylin & eosin, special histochemical stains, and immunohistochemistry
are also performed.
Additional services that are provided include radiography, investigator training and assistance with
experimental design and manuscripts/presentations. Extremely high resolution radiographic images of rodents
as well as excised tissues magnified up to 5x are taken post-mortem with an MX-20 Faxitron within the lab.
Investigative staff is routinely provided hands-on training with regard to necropsy technique and proper
submission of biological specimens and tissues. Upon request, staff pathologists actively participate in
experimental design prior to submission of animals/tissues for pathologic evaluation. Staff pathologists
also routinely contribute to manuscripts and oral/poster presentations in the form of photographs, details
about materials and methods, and interpretation of results.